A Tug-of-War Over Methionine.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 33147482.
- Also identified by DOI 10.1016/j.cmet.2020.10.016.
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Abstract
Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.
Medical subject headings
- Methionine
- Neoplasms