Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?
Level V
Where this comes from
- Record sourced from PubMed, PMID 33147483.
- Also identified by DOI 10.1016/j.cmet.2020.10.003.
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Abstract
Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al. (2020) now report that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmeshes GABAergic neurons, is reversibly altered in diabetic rats and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.
Medical subject headings
- Diabetes Mellitus, Experimental
- Fibroblast Growth Factor 1