Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 33156871.
- Also identified by DOI 10.1371/journal.pone.0241789 and PMC identifier 7647084.
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Abstract
Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.
Medical subject headings
- HIV Infections
- Interferon-gamma Release Tests
- Mycobacterium tuberculosis
- T-Lymphocytes
- Tuberculosis