A Purpose in Liquidity: Perfusing 3D Open Scaffolds Improves "Mini-gut" Morphogenesis and Longevity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33157045.
- Also identified by DOI 10.1016/j.stem.2020.10.010.
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Abstract
Channeling morphogenic signaling gradients intrinsic to intestinal epithelial stem cells, Nikolaev et al. (2020) optimized a three-dimensional microchip perfusion system that augments growth, maturation, and longevity of tubular intestinal enteroids. Reported in Nature, this system may ultimately pave the way to study human intestinal development and pathophysiology, perhaps for therapeutic discovery.
Medical subject headings
- Gastrointestinal Microbiome
- Organoids