Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33159859.
- Also identified by DOI 10.1016/j.cell.2020.09.061 and PMC identifier 7754708.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an 'all-optical' combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory.
Medical subject headings
- Hippocampus
- Place Cells
- Spatial Behavior
- Spatial Memory