Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis.
meta_analysis · Level I
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- Record sourced from PubMed, PMID 33166002.
- Also identified by DOI 10.1002/hed.26536.
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Abstract
To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. The study was performed according to the PRISMA-DTA guidelines. A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I<sup>2</sup> = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I<sup>2</sup> = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I<sup>2</sup> = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively. FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.
Medical subject headings
- Carcinoma
- Neck Dissection