Urine metabolomics of rats with chronic atrophic gastritis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33175875.
- Also identified by DOI 10.1371/journal.pone.0236203 and PMC identifier 7657567.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.
Medical subject headings
- Biomarkers
- Disease Models, Animal
- Gastritis, Atrophic
- Metabolic Networks and Pathways
- Metabolomics