Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.

Camprubí, Daniel; Almuedo-Riera, Alex; Martí-Soler, Helena; Soriano, Alex; Hurtado, Juan Carlos; Subirà, Carme; Grau-Pujol, Berta; Krolewiecki, Alejandro et al. · PLoS One · 2020

retrospective_cohort · Level III

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Abstract

Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2.

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