Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33181360.
- Also identified by DOI 10.1016/j.actbio.2020.11.010.
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Abstract
Hydroxyapatite (HA) is the main inorganic component of human bone. Inspired by nacre and cortical bone, hydroxyapatite-based coil scaffolds were successfully prepared. The scaffolds presented "brick and mortar" multi-layered structure of nacre and multi-layered concentric circular structure of cortical bone. Because of bioactive components and hierarchical structure, the scaffolds possessed good compressive strength (≈95 MPa), flexural strength (≈161 MPa) and toughness (≈1.1 MJ/m<sup>3</sup>). In addition, they showed improved angiogenesis and osteogenesis in rat and rabbit critical sized bone defect models. By mimicking co-biological systems, this work provided a feasible strategy to optimize the properties of traditional tissue engineering biological materials for vascularized bone regeneration.
Medical subject headings
- Bone Regeneration
- Durapatite