Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea).

Kohlgruber, A C; Wang, C I; Elledge, S J · Cell · 2020

basic_science · Level V

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Abstract

In this issue of Cell, Liu et al. present FucoID, a glycosyltransferase-mediated tagging platform, to biochemically label and capture antigen-specific T cells. With this technology, the authors isolate and characterize tumor-specific CD8+ and CD4+ T cells in murine tumor models. FucoID shows promise as a tool to enhance the understanding of anti-tumor immune responses.

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