Predictive role of vitamin B₁₂ in acute kidney injury in living donor liver transplantation: a propensity score matching analysis.

Abstract

We examine the association between vitamin B₁₂ level and risk for acute kidney injury (AKI) in patients undergoing living donor liver transplantation (LDLT). Retrospective observational cohort study. University hospital, from January 2009 to December 2018. A total of 591 patients who underwent elective LDLT were analysed in this study. Those with a preoperative history of kidney dysfunction, vitamin B₁₂ supplementation due to alcoholism, low vitamin B₁₂ (<200 pg/mL) or missing laboratory data were excluded. The population was classified into AKI and non-AKI groups according to Kidney Disease Improving Global Outcomes (KDIGO) criteria, and associations between perioperative factors and AKI were analysed. After 1:1 propensity score (PS) matching, the association between high vitamin B₁₂ (>900 pg/mL) and postoperative AKI was evaluated. Preoperative vitamin B₁₂ was higher in the AKI group. Potentially significant perioperative factors from univariate analyses were entered into multivariate analyses, including preoperative factors (vitamin B₁₂, diabetes), intraoperative factors (hourly urine output) and donor graft fatty change in LDLT patients. PS matching analyses with adjustment using PS revealed that high serum vitamin B₁₂ (>900 pg/mL) was associated with risk for AKI, and the risk was 2.8-fold higher in patients with high vitamin B₁₂ than in those with normal vitamin B₁₂. Higher vitamin B₁₂ was also related to a higher AKI stage. In addition, inflammatory factors (C reactive protein, white blood cells and albumin) were associated with vitamin B₁₂ level. Our study may improve the accuracy of predicting postoperative AKI by introducing preoperative vitamin B₁₂ into risk assessments for patients undergoing LDLT.