Effect of Antibiotic Use Within First 48 Hours of Life on the Preterm Infant Microbiome: A Randomized Clinical Trial.

Kim, Christina S; Grady, Nicole; Derrick, Matthew; Yu, Yueyue; Oliphant, Kaitlyn; Lu, Jing; Claud, Erika C · JAMA Pediatr · 2021

rct · Level II

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Abstract

This randomized clinical trial investigates whether withholding the standard 48 hours of intravenous empirical antibiotics immediately after birth in preterm infants protects the developing microbiome and improves clinical outcomes.

Medical subject headings