InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 33201882.
- Also identified by DOI 10.1371/journal.pone.0239354 and PMC identifier 7671525.
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Abstract
We previously identified a diazaborine series with potential for development as a new tuberculosis drug. This series has activity in vitro and in vivo and targets cell wall biosynthesis via inhibition of InhA. The overall aim of this study was to determine whether InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis. We tested the ability of two molecules of the diazaborine series to kill non-replicating M. tuberculosis in the nutrient starvation model; both molecules were bactericidal, reducing viability by >3 logs in 21 days. Activity showed similar kill rates to other InhA inhibitors (isoniazid and NITD-916). We conclude that inhibition of InhA is bactericidal against nutrient-starved non-replicating M. tuberculosis.
Medical subject headings
- Antitubercular Agents
- Inhibins
- Mycobacterium tuberculosis