Persistence of Maternal Anti-Rotavirus Immunoglobulin G in the Post-Rotavirus Vaccine Era.

Payne, Daniel C; McNeal, Monica; Staat, Mary Allen; Piasecki, Alexandra M; Cline, Allison; DeFranco, Emily; Goveia, Michelle G; Parashar, Umesh D et al. · J Infect Dis · 2021

prospective_cohort · Level II

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Abstract

To assess whether titers of anti-rotavirus immunoglobulin G persist during the post-rotavirus vaccine era, the Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) Cohort analyzed serum samples collected from Cincinnati-area mothers and young infants in 2017-2018. Rotavirus-specific antibodies continue to be transferred from US mothers to their offspring in the post-rotavirus vaccine era, despite dramatic decreases in childhood rotavirus gastroenteritis.

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