Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33214251.
- Also identified by DOI 10.1126/science.abc8301 and PMC identifier 8162921.
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Abstract
Hadzipasic <i>et al</i> (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused Aurora kinases to evolve allosteric regulation. We show that their results arise from using an implausible phylogeny and sparse sequence sampling. Addressing either problem reverses their inferences: Allostery and the amino acids that confer it were not gained during the diversification of eukaryotes but were lost in a subgroup of Fungi.
Medical subject headings
- Aurora Kinases