¹²⁹Xe MRI as a measure of clinical disease severity for pediatric asthma.

Abstract

Measurement of regional lung ventilation with hyperpolarized ¹²⁹Xe magnetic resonance imaging (¹²⁹Xe MRI) in pediatric asthma is poised to advance our understanding of disease mechanisms and pathophysiology in a disorder with diverse clinical phenotypes. ¹²⁹Xe MRI has not been investigated in a pediatric asthma cohort. We hypothesized that ¹²⁹Xe MRI is feasible and can demonstrate ventilation defects that relate to and predict clinical severity in a pediatric asthma cohort. Thirty-seven children (13 with severe asthma, 8 with mild/moderate asthma, 16 age-matched healthy controls) aged 6 to 17 years old were imaged with ¹²⁹Xe MRI. Ventilation defect percentage (VDP) and image reader score were calculated and compared with clinical measures at baseline and at follow-up. Children with asthma had higher VDP (P = .002) and number of defects per image slice (defects/slice) (P = .0001) than children without asthma. Children with clinically severe asthma had significantly higher VDP and number of defects/slice than healthy controls. Children with asthma who had a higher number of defects/slice had a higher rate of health care utilization (r = 0.48; P = .03) and oral corticosteroid use (r = 0.43; P = .05) at baseline. Receiver-operating characteristic analysis demonstrated that the VDP and number of defects/slice were predictive of increased health care utilization, asthma, and severe asthma. VDP correlated with FEV₁ (r = -0.35; P = .04) and FEV₁/forced vital capacity ratio (r = -0.41; P = .01). ¹²⁹Xe MRI correlates with asthma severity, health care utilization, and oral corticosteroid use. Because delineation of clinical severity is often difficult in children, ¹²⁹Xe MRI may be an important biomarker for severity, with potential to identify children at higher risk for exacerbations and improve outcomes.