Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients.

Bertram, Christie M; Postelnick, Michael; Mancini, Christian M; Fu, Xiaoqing; Zhang, Yuqing; Schulz, Lucas T; Bhowmick, Tanaya; Lee, Francesca et al. · Clin Infect Dis · 2021

cross_sectional · Level IV

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Abstract

Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

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