Interim PET in Diffuse Large B-Cell Lymphoma.

Abstract

In diffuse large B-cell lymphoma, early assessment of treatment response by ¹⁸F-FDG PET may trigger treatment modification. Reliable identification of good and poor responders is important. We compared 3 competing methods of interim PET evaluation. <b>Methods:</b> Images from 449 patients participating in the "PET-Guided Therapy of Aggressive Non-Hodgkin Lymphomas" trial were reanalyzed by applying the visual Deauville score and the SUV-based qPET (q = quantitative) and ΔSUV_max scales to interim PET scans performed after 2 cycles of chemotherapy. qPET relates residual lymphoma ¹⁸F-FDG uptake to physiologic liver uptake, converting the ordinal Deauville scale into a continuous scale and permitting a direct comparison with the continuous ΔSUV_max scale, which is based on SUV_max changes between baseline and interim scans. Positive and negative predictive values were calculated for progression-free survival. <b>Results:</b> When established thresholds were used to distinguish between good and poor responders (visual Deauville score 1-3 vs. 4-5; ΔSUV_max > 66% vs. ≤ 66%), the positive predictive value was significantly lower with Deauville than ΔSUV_max (38.4% vs. 56.6%; <i>P</i> = 0.03). qPET and ΔSUV_max were strongly correlated on the log scale (Pearson <i>r</i> = 0.75). When plotted along corresponding percentiles, the positive predictive value curves for qPET and ΔSUV_max were superimposable, with low values up to the 85th percentile and a steep rise thereafter. The recommended threshold of 66% SUV_max reduction for the identification of poor responders was equivalent to qPET = 2.26, corresponding to score 5 on the visual Deauville scale. The negative predictive value curves were also superimposable but remained flat between 80% and 70%. <b>Conclusion:</b> Continuous scales are better suited for interim PET-based outcome prediction than the ordinal Deauville scale. qPET and ΔSUV_max essentially carry the same information. The proportion of poor-risk patients identified is less than 15%.