An Ultrahigh-Field-Tailored T₁ -T₂ Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging.

Abstract

The assessment of vascular anatomy and functions using magnetic resonance imaging (MRI) is critical for medical diagnosis, whereas the commonly used low-field MRI system (≤3 T) suffers from low spatial resolution. Ultrahigh field (UHF) MRI (≥7 T), with significantly improved resolution and signal-to-noise ratio, shows great potential to provide high-resolution vasculature images. However, practical applications of UHF MRI technology for vascular imaging are currently limited by the low sensitivity and accuracy of single-mode (T₁ or T₂ ) contrast agents. Herein, a UHF-tailored T₁ -T₂ dual-mode iron oxide nanoparticle-based contrast agent (UDIOC) with extremely small core size and ultracompact hydrophilic surface modification, exhibiting dually enhanced T₁ -T₂ contrast effect under the 7 T magnetic field, is reported. The UDIOC enables clear visualization of microvasculature as small as ≈140 µm in diameter under UHF MRI, extending the detection limit of the 7 T MR angiography. Moreover, by virtue of high-resolution UHF MRI and a simple double-checking process, UDIOC-based dual-mode dynamic contrast-enhanced MRI is successfully applied to detect tumor vascular permeability with extremely high sensitivity and accuracy, providing a novel paradigm for the precise medical diagnosis of vascular-related diseases.