Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty.
other · Level V
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- Record sourced from PubMed, PMID 33264644.
- Also identified by DOI 10.1016/j.cmet.2020.11.012 and PMC identifier 8939237.
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Abstract
Childhood obesity has been linked to early puberty in girls but the mechanism(s) by which overnutrition triggers pubertal onset remain unclear. In a recent issue of Cell Metabolism, Heras et al., 2020 implicate a non-canonical central ceramide to ovarian sympathetic innervation pathway as a novel mediator of obesity-induced pubertal acceleration in female rats.
Medical subject headings
- Puberty, Precocious