News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33268551.
- Also identified by DOI 10.1158/1078-0432.CCR-20-4067.
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Abstract
Data indicate that ultrahigh dose rate (>10<sup>6</sup> Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation fraction size, total dose, and number of fractions are critical parameters for FLASH-RT cognitive sparing without compromising tumor response.<i>See related article by Montay-Gruel et al., p. 775</i>.
Medical subject headings
- Glioblastoma
- Radiation Oncology