Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis.
review · Level V
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- Record sourced from PubMed, PMID 33306505.
- Also identified by DOI 10.14309/ajg.0000000000001042 and PMC identifier 7775325.
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Abstract
It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.
Medical subject headings
- Hepatitis, Alcoholic
- Keratin-18