Proteostasis is adaptive: Balancing chaperone holdases against foldases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33315891.
- Also identified by DOI 10.1371/journal.pcbi.1008460 and PMC identifier 7769611.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to different conditions? Here, we explore a biophysical cost-benefit principle, namely that the cell should keep its proteome as folded as possible at the minimum possible energy cost. This can be achieved by differential expression of chaperones-balancing foldases (which accelerate folding) against holdases (which act as parking spots). The model captures changes in the foldase-holdase ratio observed both within organisms during aging and across organisms of varying metabolic rates. This work describes a simple biophysical mechanism by which cellular proteostasis adapts to meet the needs of a changing growth environment.
Medical subject headings
- Molecular Chaperones
- Protein Folding
- Proteostasis