Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 33328328.
- Also identified by DOI 10.1126/scitranslmed.abc2888 and PMC identifier 7611886.
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Abstract
The longitudinal dynamics of the most promising biofluid biomarker candidates for Huntington's disease (HD)-mutant huntingtin (mHTT) and neurofilament light (NfL)-are incompletely defined. Characterizing changes in these candidates during disease progression could increase our understanding of disease pathophysiology and help the identification of effective therapies. In an 80-participant cohort over 24 months, mHTT in cerebrospinal fluid (CSF), as well as NfL in CSF and blood, had distinct longitudinal trajectories in HD mutation carriers compared with controls. Baseline analyte values predicted clinical disease status, subsequent clinical progression, and brain atrophy, better than did the rate of change in analytes. Overall, NfL was a stronger monitoring and prognostic biomarker for HD than mHTT. Nonetheless, mHTT has prognostic value and might be a valuable pharmacodynamic marker for huntingtin-lowering trials.
Medical subject headings
- Huntingtin Protein
- Huntington Disease
- Neurofilament Proteins