Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 33331820.
- Also identified by DOI 10.7554/eLife.63430 and PMC identifier 7775105.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by <i>Pseudomonas aeruginosa</i> that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and <i>P. aeruginosa</i> specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.
Medical subject headings
- Anti-Bacterial Agents
- COVID-19
- Lymphocyte Activation
- Pneumonia, Ventilator-Associated
- Pseudomonas Infections
- SARS-CoV-2
- T-Lymphocytes