Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33367731.
- Also identified by DOI 10.1093/infdis/jiaa789 and PMC identifier 7799006.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
Medical subject headings
- Extracellular Traps
- Neutrophils
- Oxazines
- Pyridines
- COVID-19 Drug Treatment