What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

Villemagne, Victor L; Lopresti, Brian J; Doré, Vincent; Tudorascu, Dana; Ikonomovic, Milos D; Burnham, Samantha; Minhas, Davneet; Pascoal, Tharick A et al. · J Nucl Med · 2021

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Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

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