Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 33411899.
- Also identified by DOI 10.1093/cid/ciaa1909 and PMC identifier 8825772.
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Abstract
We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.
Medical subject headings
- Anti-Bacterial Agents
- Pseudomonas aeruginosa