The Rise of Molecular Glues.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33417864.
- Also identified by DOI 10.1016/j.cell.2020.12.020.
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Abstract
2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.
Medical subject headings
- Biological Products