One Big Step to a Neuron, Two Small Steps for miRNAs.

Herdy, Joseph R; Karbacher, Lukas; Mertens, Jerome · Cell Stem Cell · 2021

editorial · Level V

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Abstract

Direct cell fate conversion of human somatic cells into induced neurons (iNs) is often regarded as a highly concerted one-step process. In this issue of Cell Stem Cell, Cates et al. (2021) dissect the iN conversion trajectory into two largely independent steps and identify key players at each stage.

Medical subject headings