Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33417870.
- Also identified by DOI 10.1016/j.stem.2020.12.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Blastocyst complementation represents a powerful technique for interspecies organogenesis but is limited by low chimerism due to developmental incompatibilities. In this issue of Cell Stem Cell,Nishimura et al. (2021) circumvent early developmental barriers by disabling Igf1r in host embryos, conferring donor cells with a growth advantage from mid-gestation onward.
Medical subject headings
- Chimera
- Pluripotent Stem Cells