Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33417872.
- Also identified by DOI 10.1016/j.stem.2020.12.006.
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Abstract
The regeneration potential of axons projecting from retinal ganglion cells (RGCs) is lost shortly after birth. In Nature, Lu et al. (2020) demonstrate that epigenetic reprogramming of RGCs by overexpression of Oct4, Sox2, and Klf4 leads to axon regeneration and restoration of vision in a glaucoma model and aged mice.
Medical subject headings
- Axons
- Nerve Regeneration