Tipping the Scale: MYC Gains Weight in Fanconi Anemia Bone Marrow Failure Progression.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33417873.
- Also identified by DOI 10.1016/j.stem.2020.12.013.
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Abstract
Fanconi anemia (FA) is an inherited syndrome of bone marrow failure (BMF) due to disrupted DNA repair. In this issue of Cell Stem Cell, Rodríguez et al. (2021) show that blood stem cells from FA patients have abnormal and inflammation-induced MYC expression, which promotes their proliferation in the face of increasing DNA damage.
Medical subject headings
- Fanconi Anemia