Ultraviolet radiation drives mutations in a subset of mucosal melanomas.
Where this comes from
- Record sourced from PubMed, PMID 33431815.
- Also identified by DOI 10.1038/s41467-020-20432-5 and PMC identifier 7801393.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.
Medical subject headings
- Melanoma
- Mucous Membrane
- Mutation
- Skin Neoplasms
- Ultraviolet Rays