Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015-2016 to 2018-2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network.

Ferdinands, Jill M; Gaglani, Manjusha; Martin, Emily T; Monto, Arnold S; Middleton, Donald; Silveira, Fernanda; Talbot, H Keipp; Zimmerman, Richard et al. · Clin Infect Dis · 2021

retrospective_cohort · Level III

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Abstract

We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata-associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%-9% per month postvaccination.

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