Collateral sensitivity associated with antibiotic resistance plasmids.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33470194.
- Also identified by DOI 10.7554/eLife.65130 and PMC identifier 7837676.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the clinically important carbapenem-resistance conjugative plasmid pOXA-48. In addition, we describe the conservation of CS in clinical <i>E. coli</i> isolates and its application to selectively kill plasmid-carrying bacteria. Our results provide new insights that establish the basis for developing CS-informed treatment strategies to combat plasmid-mediated ABR.
Medical subject headings
- Anti-Bacterial Agents
- Carbapenems
- Drug Collateral Sensitivity
- Drug Resistance, Multiple, Bacterial
- Escherichia coli
- Plasmids