Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy.
review · Level V
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- Record sourced from PubMed, PMID 33472888.
- Also identified by DOI 10.1158/0008-5472.CAN-20-3613.
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Abstract
<i>MYC</i> is embedded in the transcriptional oasis of the <i>8q24</i> gene desert. A plethora of genomic elements has roles in <i>MYC</i> aberrant expression in cancer development by interacting with transcription factors and epigenetics regulators as well as altering the structure of chromatin at the <i>MYC</i> locus and tissue-specific long-range enhancer-promoter contacts. Furthermore, MYC is a master regulator of several human cancers by modulating the transcription of numerous cancer-related genes through epigenetic mechanisms. This review provides a comprehensive overview of the three-dimensional genomic organization around <i>MYC</i> and the role of epigenetic machinery in transcription and function of MYC as well as discusses various epigenetic-targeted therapeutic strategies in MYC-driven cancers.
Medical subject headings
- Chromatin
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Neoplasms
- Transcription Factors