Does protein aggregation drive postmitotic tissue degeneration?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33472954.
- Also identified by DOI 10.1126/scitranslmed.aax0914 and PMC identifier 9447413.
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Abstract
Pharmacological evidence, from clinical trials where patients with systemic amyloid diseases are treated with disease-modifying therapies, supports the notion that protein aggregation drives tissue degeneration in these disorders. The protein aggregate structures driving tissue pathology and the commonalities in etiology between these diseases and Alzheimer's disease are under investigation.
Medical subject headings
- Alzheimer Disease
- Amyloidosis