Catalytic enantioselective C(sp<sup>3</sup>)-H functionalization involving radical intermediates.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 33473126.
- Also identified by DOI 10.1038/s41467-020-20770-4 and PMC identifier 7817665.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recently, with the boosted development of radical chemistry, enantioselective functionalization of C(sp<sup>3</sup>)-H bonds via a radical pathway has witnessed a renaissance. In principle, two distinct catalytic modes, distinguished by the steps in which the stereochemistry is determined (the radical formation step or the radical functionalization step), can be devised. This Perspective discusses the state-of-the-art in the area of catalytic enantioselective C(sp<sup>3</sup>)-H functionalization involving radical intermediates as well as future challenges and opportunities.