Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 33481781.
- Also identified by DOI 10.1371/journal.pone.0239353 and PMC identifier 7822546.
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Abstract
The phenoxyalkylimidazoles (PAI) are an attractive chemical series with potent anti-tubercular activity targeting Mycobacterium tuberculosis respiration. Our aim was to determine if the PAI compounds are subject to efflux. Two analogs containing an oxadiazole had improved potency in the presence of the efflux inhibitors reserpine and carbonyl cyanide m-chlorophenylhydrazine, whereas the potency of analogs with a diazole was not affected.
Medical subject headings
- Mycobacterium tuberculosis
- Oxadiazoles
- Phenols