Breathing new life into the rational design of Alzheimer's therapeutics.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33482095.
- Also identified by DOI 10.1016/j.cell.2020.12.036.
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Abstract
γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.
Medical subject headings
- Alzheimer Disease