Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 33490315.
- Also identified by DOI 10.1016/j.bonr.2021.100746 and PMC identifier 7811042.
- Licence recorded as CC BY-NC-ND.
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Abstract
Although diuretics are often prescribed to control fluid overload, they can change Chronic kidney disease-mineral and bone disorder (CKD-MBD) parameters. Previous studies have shown an association between diuretic prescription and changes in both calciuria and parathormone levels. However, the causal relationship could not be confirmed. In addition, the effects of diuretics on bone mineral density and turnover markers are yet to be established. To evaluate the effects of diuretics on CKD-MBD, we have performed a prospective randomized trial comparing hydrochlorothiazide with furosemide in a stage 3CKD population followed for 1 year. Furosemide increased bone remodeling and parathormone levels, whereas hydrochlorothiazide attenuated parathyroid hormone rise and decreased bone turnover markers.