Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 33495439.
- Also identified by DOI 10.1038/s41467-020-20443-2 and PMC identifier 7835232.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10<sup>-10</sup>, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h<sup>2</sup><sub>SNP</sub> = 0.34) when compared to ADHD without DBDs (h<sup>2</sup><sub>SNP</sub> = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r<sub>g</sub> = 0.81) and anti-social behaviors (r<sub>g</sub> = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
Medical subject headings
- Attention Deficit Disorder with Hyperactivity
- Attention Deficit and Disruptive Behavior Disorders
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide