Dual-Effective Chronic Wounds Management System through a Monoglyceride Binary Blend Matrix Based Thermal-Responsive Phase-Transition Substrate.

Abstract

A new monoglyceride-based heat-sensitive substrate is proposed, for the first time, as a wound management system. First, an appropriate portion of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) is mixed to provide a thermal phase responsive matrix (GMO-GMS, GG). Subsequently, to improve the photothermal responsive and antibacterial performance, silver nanoparticles (Ag) decorated reduced graphene oxide (rGO) nanocomposite (rGO-Ag) is added to the GG matrix to obtain (GG-rGO-Ag). According to the systematic studies from uninfected, infected, and diabetic wound models, by applying near infrared (NIR) laser, the phase change of GG-rGO-Ag can be triggered to release Ag on demand for sterilization. More importantly, this smart GG substrate can also promote the production of vascular endothelial growth factor protein, thus serving as a NIR defined mufti-effective wound management system.