Perspectives on skeletal muscle stem cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33514709.
- Also identified by DOI 10.1038/s41467-020-20760-6 and PMC identifier 7846784.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G<sub>alert</sub> states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine.
Medical subject headings
- Muscle, Skeletal
- Muscular Diseases
- Regenerative Medicine
- Stem Cell Transplantation
- Stem Cells