Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 33521696.
- Also identified by DOI 10.1016/j.xcrm.2020.100164 and PMC identifier 7817775.
- Licence recorded as CC BY-NC-ND.
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Abstract
Convalescent plasma (CP) is widely used to treat COVID-19, but without formal evidence of efficacy. Here, we report the beneficial effects of CP in a severely ill COVID-19 patient with prolonged pneumonia and advanced chronic lymphocytic leukemia (CLL), who was unable to generate an antiviral antibody response of her own. On day 33 after becoming symptomatic, the patient received CP containing high-titer (ID<sub>50</sub> > 5,000) neutralizing antibodies (NAbs), defervesced, and improved clinically within 48 h and was discharged on day 37. Hence, when present in sufficient quantities, NAbs to SARS-CoV-2 have clinical benefit even if administered relatively late in the disease course. However, analysis of additional CP units revealed widely varying NAb titers, with many recipients exhibiting endogenous NAb responses far exceeding those of the administered units. To obtain the full therapeutic benefits of CP immunotherapy, it will thus be important to determine the neutralizing activity in both CP units and transfusion candidates.
Medical subject headings
- COVID-19