Fetal brain tissue characterization at 1.5 T using STrategically Acquired Gradient Echo (STAGE) imaging.
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- Record sourced from PubMed, PMID 33523305.
- Also identified by DOI 10.1007/s00330-020-07618-7.
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Abstract
To estimate human fetal brain MRI tissue properties including apparent T<sub>1</sub> (T<sub>1app</sub>) and apparent proton density (PD<sub>app</sub>) by using a rapid multi-contrast acquisition protocol called STrategically Acquired Gradient Echo (STAGE) imaging. STAGE data were collected using two flip angles (15° and 60°, with a TR = 600 ms) for 30 pregnant women at 1.5 T (15 healthy controls: gestational age (GA) range 19 + 1/7 weeks to 34 + 5/7 weeks; 11 abnormal subjects with ventriculomegaly: GA range 21 + 5/7 weeks to 31 + 5/7 weeks; 4 subjects with other abnormalities). Both T<sub>1app</sub> and PD<sub>app</sub> maps of the fetal brain were calculated from the STAGE data. A region-of-interest-based approach was used to measure T<sub>1app</sub> and PD<sub>app</sub> in the subplate/intermediate zone (SP/IZ), cortical plate (CP), and cerebrospinal fluid (CSF) in the fetal brain. The ratios of T<sub>1appSP/IZ</sub>/T<sub>1appCP</sub> and PD<sub>appSP/IZ</sub>/PD<sub>appCP</sub> were larger than unity while T<sub>1appSP/IZ</sub>/T<sub>1appCSF</sub> and PD<sub>appSP/IZ</sub>/PD<sub>appCSF</sub> were both less than unity. STAGE imaging provides a potential practical approach to estimate multi-parametric properties of the human fetal brain. • STAGE is feasible in measuring fetal brain tissue properties. • Water content in cortical plate and subplate/intermediate zone approaches that of cerebrospinal fluid in early gestational ages.
Medical subject headings
- Brain
- Magnetic Resonance Imaging