Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33527954.
- Also identified by DOI 10.1039/d0sm01817a.
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Abstract
A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.
Medical subject headings
- Nanospheres