Granulomatous interstitial nephritis in granulomatosis with polyangiitis mimicking leprosy: A case report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 33532434.
- Also identified by DOI 10.4103/jfmpc.jfmpc_1070_20 and PMC identifier 7842479.
- Licence recorded as CC BY-NC-SA.
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Abstract
Granulomatous polyangiitis (GPA) is a small vessel vasculitis commonly affecting the upper and lower respiratory tracts and kidneys. About 90% of the cases are associated with ANCA, namely, PR3-ANCA and MPO-ANCA. Herein, we describe a patient of GPA who presented with anasarca, sensory neuropathy, recurrent upper airway congestion, epistaxis, and rapidly progressive glomerulonephritis. Granulomatous interstitial nephritis and necrotizing granulomatous inflammation of the nasal septum were found on biopsy of the kidney and nasal septum, respectively both of which are rare findings. PR3-ANCA and MPO-ANCA were negative. Fulfilling the ACR criteria, this case of GPA proves that biopsy is still the gold standard of diagnosis.