Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43.
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- Record sourced from PubMed, PMID 33535096.
- Also identified by DOI 10.1016/j.cmet.2021.01.009 and PMC identifier 8407036.
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Abstract
Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring hepatocytes via connexin 43, thus propagating ER stress and promoting hepatosteatosis and insulin resistance.
Medical subject headings
- Endoplasmic Reticulum Stress
- Insulin Resistance